How Do You Calculate Sink Condition In Dissolution?

What is sink and non sink condition?

In the European Pharmacopeia, sink conditions are defined as a volume of dissolution medium that is at least three to ten times the saturation volume.

Otherwise, it is in non-sink conditions.

Mathematical simulation is a fast way to predict and clarify the process and mechanism of dissolution tests..

What are the types of dissolution?

There are seven USP-defined types of dissolution apparatus: baskets, paddles, reciprocating cylinders, flow through cells, paddle over disk types, cylinders, and reciprocating holders. Although USP 2 paddles are most widely used, most dissolution apparatus incorporate any number of each type (often all of them) .

How do you maintain sink conditions in dissolution?

If you put a spoon of sugar into a beaker of water it will dissolve readily. A second spoon will also dissolve. But keep adding spoonfuls and it becomes slower for the sugar to dissolve until at some point it becomes impossible for any more to dissolve as the solution becomes saturated.

How many types of dissolution are there?

The dissolution test. It is worth reviewing the dissolution test, its historical evolution and some of its significant limitations. The various different pharmacopoeias describe four main types of dissolution apparatus; one (basket), two (paddle), three (reciprocating cylinder and four (flow through) (USP<711>).

Why dissolution is performed on 6 tablets?

Dissolution test is done to verify the release of drug in the solution from the tablet because of binders, granulation, mixing and the coating may affect the release of drug from tablets. … Dissolution test is done using 6 units or dosage forms.

What is phosphate buffer used for?

Phosphate buffered saline (PBS) is a non-toxic solution used in many biological laboratories. Unlike water, PBS prevents cells rupturing or shrivelling up due to osmosis.

Why is dissolution important?

Dissolution is the process in which a substance forms a solution. Dissolution testing measures the extent and rate of solution formation from a dosage form, such as tablet, capsule, ointment, etc. The dissolution of a drug is important for its bioavailability and therapeutic effectiveness.

Why is multimedia dissolution needed?

Multimedia dissolution is to mimic the invivo condition by doing invitro test and pH/buffer selection is based on the exposure of drug from stomach to intestine/colon.

How do you determine sink conditions for dissolution?

Sink condition is mentioned a lot when it comes to dissolution testing, but the importance of it to dissolution testing is left out. Sink condition is the ability of the dissolution media to dissolve at least 3 times the amount of drug that is in your dosage form.

Why is 900 ml dissolution media?

Most likely, the volume was lowered to 900mL to account for volume displacement from the product and stirring shaft. This gives some wiggle room in the test, so that the vessel doesn’t spill over during the dissolution.

Why phosphate buffer is used in dissolution?

The higher buffer capacity of phosphate maintains the pH at the solid-liquid interface lower than, but closer, to the basic environment of the bulk, in relative to the bicarbonate system. Thus, a greater extent ionization of acidic drugs and the subsequent increase of drug dissolution in the phosphates are present.

What are the factors affecting dissolution?

Factors that affect the dissolution of a drug product include the intrinsic properties of the API (e.g., solubility, wettability, particle size, surface area, morphology, polymorphs), the formulation composition and characteristics (e.g., excipients, hardness, manufacturing process), and the dissolution method used for …

What is s1 and s2 in dissolution?

S1 or S2. The quantity, Q is the amount of dissolved active. Dissolution Medium—Proceed as directed for Immediate- ingredient. specified in the individual monograph, expressed Release Dosage Forms under Apparatus 1 and Apparatus 2.

What is Q point in dissolution?

Thread: Q Value quantity ‘Q’ is the amount of dissolved active ingredient specified in the monograph. Required to be released in the stated time, expressed as a percentage of labelled strength, then the batch of the tablet or capsules is acceptable, if each unit is not less than Q + 5 %.

Why sinkers are used in dissolution?

Capsule Sinkers. Floating dosage forms rarely dissolve at a reproducible rate. Using a sinker in Apparatus 2 fixes the dosage form to a certain point and aids reproducibility. Sinkers can also be useful where dosage forms may stick to the sides of the vessel.

Why do we use basket in dissolution?

In the basket dissolution method, a different apparatus is placed at the end of the rotating shaft. This apparatus is called a basket. … The sticky tablets containing HPMC or similar compounds as a binder are tested using a basket because tablet swells in water and may stick to the walls of the dissolution vessel.

Why SLS is used in dissolution media?

Abstract. Purpose: Sodium lauryl sulfate (SLS) is a commonly used surfactant in dissolution media for poorly water soluble drugs. … Results: SLS significantly slowed down the dissolution of gelatin shells at pH < 5. Visually, the gelatin shells transformed into some less-soluble precipitate under these conditions.

Why surfactant used in dissolution?

Surfactants are used in dissolution test methods to improve the solubility or wettability of a drug. Sometimes the decision to use a surfactant is based solely on the fact that it will facilitate drug dissolution and not on any further study.